By RT-qPCR and western blot, we investigated WWP1 expression levels in several CRC cell lines with different mutation statuses (KRAS-mutant: SW480, HCT116; BRAF-mutant: RKO, HT29; wild type: Caco-2, CW2) and in a normal colon epithelial cell line (FHC). This evidence concerns the gene KRAS and colorectal carcinoma.