TGFB1 and colonic neoplasm: Remodeling of the actin cytoskeleton with the inhibition of filopodia and possibly lamellipodia is consistent with previous results showing that aspirin and salicylate inhibit TGF-β1-induced EMT in A549 lung cancer cells34, colon cancer cells35, and human lens epithelial cells36, and salicylates can inhibit epithelial cells at the leading edge of the epithelium.