However, telomerase, p53, and p21 were significantly (P = 0.001, P = 1.8 × 10−5, P = 2.2 × 10−8) higher in khat chewers of BC group than khat chewers of the control group by 16%, 37.2%, and 67.3% respectively. The gene discussed is TP53; the disease is breast cancer.