TP53 and breast cancer: Similarly, p53 in khat chewers and those that were OC users and khat chewers of the BC patients were significantly (P = 0.012, P = 0.0001) higher by 32.8% and 50.4% as compared with the respective non-OC users non-khat chewers group; whereas it was borderline-significantly higher in the OC user group by 21.6% (Table 4).