Moreover, when the cribriform and non-cribriform lesions were separated, the epithelial lactate pool was also found to be significantly increased in non-cribriform high %GP4 lesions compared to both high %GP4 ICC tumours and low %GP4 disease (P < 0.05 for all; Fig. 7a, b and Supplementary Fig. 2b where patient-to-patient variation illustrates the differences between the three phenotypes). This evidence concerns the gene CD36 and neoplasm.