Interestingly, the large interaction between DNAm and TF activity (TFact) for IRF9, IRF1, STAT2, STAT1, STAT3, TFDP1, FOXM1, E2F3, E2F2, GLI2, and RUNX3 was restricted to SLE patients (Fig. 5a, b). This evidence concerns the gene TFDP1 and systemic lupus erythematosus.