The strongest (and negative) associations were found between IL1RII levels and SLE-DMPs at a number of IRGs such as PARP9 and IFI44L. We found SLE CpG-cytokine association for TNFa (VRK2, PARP9), IL1ra (BST2, ATP10A), IL1RII (IFITM1, ARID5B), MCP2 (IFI44L, CMPK2), and IP10 (NLRC5, B2M) which were not observed in CTRLs. Here, ARID5B is linked to systemic lupus erythematosus.