Interestingly, the large interaction between DNAm and TF activity (TFact) for IRF9, IRF1, STAT2, STAT1, STAT3, TFDP1, FOXM1, E2F3, E2F2, GLI2, and RUNX3 was restricted to SLE patients (Fig. 5a, b). Here, TF is linked to systemic lupus erythematosus.