We observed an enrichment of the list of unique 549 SLE differentially methylated genes (DMG) among known drug targets (Fold enrichment of 1.4, P < 0.01 in phase 1 or above in OpenTargets and Informa databases), and identified a total of 62 DMG being known drug targets, including 8 known SLE drug targets: SYK, JAK3, BCL2, PIK3CD, VDR, BTLA, FGR, GDP2, and NDUFS8 (Supplementary Table 5 and Fig. 6). Here, BCL2 is linked to systemic lupus erythematosus.