Not unexpectedly, the top SLE-DMPs implicated large reductions of DNAm at IRGs and genes enriched in IFN pathways (Supplementary Table 2), as for example IFI44L, MX1, NLRC5, IFITM1, IFIT1, IRF9 or PARP9 but also genes involved in antigen processing and class I presentation (TAP1 and B2M). Here, IRF9 is linked to systemic lupus erythematosus.