IRF9 and systemic lupus erythematosus: Interestingly, the large interaction between DNAm and TF activity (TFact) for IRF9, IRF1, STAT2, STAT1, STAT3, TFDP1, FOXM1, E2F3, E2F2, GLI2, and RUNX3 was restricted to SLE patients (Fig. 5a, b).