For example, in the KLF4 gene module drawn from patient 168, the candidate AML gene SETD7 connected KLF4 with other known AML genes including TP53, STAT3, DNMT1, PCNA, and MDM2. However, this two-hop gene module did not appear in other patients (Fig. 6e). Here, STAT3 is linked to acute myeloid leukemia.