This is consistent with CGMega that attributes HiC-1, HiC-5, chromatin accessibility and active histone modification H3K4me3 to ADIPOR1. (iii) Similar to ADIPOR1, gene ALOX12 (in cluster-3) were significantly upregulated in multiple breast cancer cell lines, which protect breast cancer cell from chemotherapy-induced growth arrest and apoptosis46,47, suggesting the importance of transcription regulation to ALOX12. (iv) Despite these isolated evidences, we collected RNA-seq data of breast cancers from TCGA project and identified differentially expressed genes (DEGs). The gene discussed is HIC1; the disease is breast cancer.