Notably, the genes induced by the infection were enriched in multiple immune activation pathways, including cytokine-cytokine receptor interaction (e.g., Il22, Tnfrsf9 and Clcf1), JAK-STAT signaling pathway (e.g., Stat3), and chemokine signaling pathway (e.g., Ccr7) (Supplementary Fig. S4F, G)33–35. This evidence concerns the gene TNFRSF9 and infection.