IFNB1 and myeloid sarcoma: QPCR results showed that RNF213 expression was higher in CD4+ T cells from MS patients who exhibited a positive response to IFN-β and further increased following IFN-β stimulation, whereas the expression of RNF213 was lower in non-responsive MS patients and remained unchanged after IFN-β stimulation (Supplementary Fig. 9I).