CD4 and ancylostomiasis: Through the combination of a controlled human hookworm infection model and high-dimensional immunophenotyping, using mass cytometry, we show that a first-in-life hookworm infection with 50 Na-L3 larvae lasting two years remodels the immune system characterized by alterations in circulating immune cells that comprised of pDC, basophils, Tregs, as well as CD4+T cells (Fig. 5).