For non-small cell lung cancer (NSCLC), Pembrolizumab is recommended for patients with high PD-L1 expression, while for those with low or unknown PD-L1 expression levels, combinations of Nivolumab with Ipilimumab and chemotherapy, or Pemetrexed with platinum-based chemotherapy are recommended. The gene discussed is CD274; the disease is non-small cell lung carcinoma.