For example, EGF promotes endothelial cell proliferation by binding to the EGF receptor (EGFR) and increases the secretion of VEGF by human pulmonary smooth muscle cells.394 In addition to the EGF family, the family of fibroblast growth factors (FGFs) and their receptors may play a significant role in tumor angiogenesis, as their overexpression has been observed across a wide range of malignancies with prognostic significance395; however, the underlying mechanisms are not yet fully understood. This evidence concerns the gene VEGFA and neoplasm.