Published data demonstrated that 50% of patients in a clinical trial using viral protein HPV-16 E7 TCR-T cell treatment for metastatic HPV-associated cancers had a positive response.189 In addition, results from eight ongoing clinical trials investigating the combination of anti-PD-1/anti-PD-L1 and TCR-T cell treatment for metastatic solid tumors are not yet available. Here, CD274 is linked to cancer.