CD274 and neoplasm: Another experiment demonstrated that in a subcutaneous model of MC38 colon cancer,426 PLGA nanoparticle therapy was as effective as treatment with soluble anti-PD-L1 monoclonal antibody (mAb), resulting in significantly reduced tumor growth.427 In other studies, Chi-Son Chang and colleagues reported that fenbendazole-incorporated PLGA nanoparticles exerted significant anticancer effects in epithelial ovarian cancer cells and xenograft models, including patient-derived xenografts (PDX).428 PLGA has also been involved in preclinical studies for combination therapy.