IRF5 and neoplasm: Researchers have developed a hollow mesoporous Prussian blue (HMPB) nanosystem disguised by a macrophage membrane.424 The released iron ions promoted the differentiation of M1-like tumor-associated macrophages (TAMs) through the interferon regulatory factor 5 (IRF5) pathway, stimulated cytotoxic T cells, and generated an effective antitumor effect.425 The applications and therapeutic strategies involving inorganic nanomedicines are highly innovative and cover a broad range of approaches.