DNER and neoplasm: For example, Liu et al. successfully combined a PI3K inhibitor, the downstream of TROY, with Sorafenib to suppress tumor development in a HCC mouse model.454 Jiang et al. demonstrated that the combination of ARV-771 and romidepsin keep tumor grew more slowly than HDAC or BET agent alone in ESCC xenograft.455 The combination of small molecular inhibitor and CRISPR system as a drug screening system to find neoantigen is also another application in basic research.