One study reported that they successfully established a co-delivery PNPs system composed of sg-VEGFR2 and Cas9, which led to more than 70% suppression of HepG2-induced HCC tumor progression.268 Additionally, Wu et al. utilized an sgHMGA2 PNPs system to achieve high-efficiency delivery (95%) and editing (82%) in gastric cancer.269 This system was shown to decrease immune responses in mice that actively targeted breast cancer tumor cells, aiding in the prevention of tumor re-growth upon re-challenge. The gene discussed is KDR; the disease is neoplasm.