CD46 is often upregulated on tumor cells from leukemia, gastrointestinal cancers, gynecological cancers, and lung cancer,304 which can be recognized by measles viruses and some subtypes of adenoviruses.305 The most commonly used vector, herpes simplex viruses, utilize the herpesvirus entry mediator (HVEM) and nectin-1 to enter tumor cells.306,307. The gene discussed is CD46; the disease is neoplasm.