GPC3 and familial pancreatic carcinoma: Common tumor-associated antigen (TAA) targets include CEA, HER2, GPC3, EpCAM, etc. are often expressed on vital organs, which severely limit the application of CAR-T in solid tumors.162 The continuous discovery of highly expressed and CAR-T-developable targets has led to rapid growth of clinical pipelines, such as GPC3 highly expressed in liver cancer, CLDN18.2 highly expressed in gastric and pancreatic cancer, EGFRvIII in glioblastoma.163,164