Lu Zhimin’s team published research indicating that the gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1 (PCK1) has protein kinase activity and phosphorylates protein substrates using GTP as the phosphate donor, continuously stimulating tumor lipid synthesis to promote tumor progression.468 These data further attracted researchers’ attention to accelerating the development of metabolic-related drugs. Here, PCK1 is linked to neoplasm.