In addition to the regulation by monomeric and homodimeric TFs, the expression of cancer-associated genes can also be modulated by higher order functional relationships between TFs at promoter sequences, including cooperativity and antagonism between TF pairs (Jolma et al, 2015; Morgunova & Taipale, 2017; Ibarra et al, 2020; Hu et al, 2022). The gene discussed is TF; the disease is cancer.