Compared with the proportion of TF families in the array, we found an over-representation of interactions involving the EBF1, grainyhead, NHR, and AP-2 families (Fig 2F), which are known to play important roles in tumor growth and progression via diverse mechanisms (Tsigelny et al, 2014; Zhang et al, 2020; Hu et al, 2021; Carrasco et al, 2023). This evidence concerns the gene TF and neoplasm.