Indeed, AP-2 family members such as TFAP2A, TFAP2B, and TFAP2C have been shown to be involved in different cancer types such as glioblastoma, melanoma, acute myeloid leukemia, pancreatic cancer, and colorectal cancer (Kolat et al, 2019; Raap et al, 2021). The gene discussed is TFAP2B; the disease is melanoma.