The role of these polymorphisms, especially IL-1B (+3953) (p = 0.023), in the occurrence of biological complications such as pain, mobility, peri-implantitis, peri-implant mucositis, and dental implant loss was also mentioned by Sampaio Fernandes et al in an analysis of 229 implants from 58 patients with implant-retained overdentures.3 Here, IL1B is linked to Peri-Implantitis.