IL4 and Peri-Implantitis: The genetic alterations of IL-1B (−511) were reported in three articles4, 5, 6and the absence of an association with dental implant failure was observed in all of them, while IL-1B (+3954) was associated with the severity of progression of peri-implantitis and consequent reduction in implant survival in three of the four studies cited,5, 6, 9, 11and was only negative in Melo et al.6IL-4 (+33) and IL-4 (−590) were only studied by Pigossi et al,10showing an association only in the first polymorphism reported.