REN and metabolic disease: The strong association between metabolic diseases and critical illness could be due to the physiological changes induced by these diseases; for example, hypertension alters the balance of the renin‐angiotensin‐aldosterone system pathway, downregulating the angiotensin‐converting enzyme (ACE) 2 and increasing the ACE/angiotensin II, facts that favor colonization and infection by SARS‐CoV‐2 [46].