APCS and coronary artery disorder: Cis-MR analysis suggested that higher plasma SAP value was associated with increased coronary heart disease risk (OR 1.03, 95%CI 1.01; 1.05), greater total brain volume (0.06 SD, 95%CI 0.02; 0.10), lower systolic blood pressure (SBP) (−0.16 mm Hg, 95%CI −0.26; −0.07) and lower diastolic blood pressure (DBP) (figure 5; electronic supplementary material, table S11).