Both pretreatment T and N stage showed some variation (Fig. 1b, Supplementary Table S3) while the frequencies of the main molecular profiles were within expected ranges, albeit different for some genetic variables such as APC and TP53 mutations and CIN that were more common in Grampian than Aristotle (Fig. 1c and d, Supplementary Figure S2a, Supplementary Table S3). Here, APC is linked to cervical squamous intraepithelial neoplasia.