Interestingly, an I428S mutation in CCM2 has been reported in a patient diagnosed with vascular dementia (CCM2I428S [Mönkäre et al., 2021]), and this isoleucine is on the same face of the CTH helix as the mutations we designed, so we predicted it too would impact the TLNRD1–CCM2 binding interface. This evidence concerns the gene TLNRD1 and vascular dementia.