It has been reported that NLRP3 activation promotes acute intestinal injury in NEC and the blockage of NLRP3 ameliorates injury.64 However, some studies have demonstrated that FXR negatively regulates the NLRP3 inflammasome in cholestasis-associated sepsis and reticulum stress-induced liver injury.45,65 The role of FXR in regulating the NLRP3 inflammasome is contradictory, and a potential reason for this discrepancy is that different types of disease models have been used. Here, NR1H4 is linked to necrotizing enterocolitis.