Western blotting results showed that CRY2 expression increased in the AD+SD group compared to the AD group (n = 6, p = 0.0115), increased in the AD+LV-CRY2 group compared to the AD group (n = 6, p = 0.0478), and increased in the AD+LV-NC group compared to the AD group (n = 6, p = 0.0423; Fig 3J). The gene discussed is CRY2; the disease is Alzheimer disease.