Compared to the AD group, the expression of CISH mRNA (n = 6, p = 0.0106; Fig 5A) and protein (n = 3, p = 0.0170; Fig 5B) was significantly decreased in the hippocampus of AD+SD mice, but there were no significant differences in SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, or SOCS7 between the two groups. The gene discussed is SOCS2; the disease is Alzheimer disease.