,4 For example, while studies have shown that adults with OI have lower serum sclerostin levels vs age- and sex-matched controls (p<.0001), mean serum sclerostin levels in individuals with OI type III/IV were observed to be lower vs type I, although this outcome was not statistically significant (p=.14).27 The gene discussed is SOST; the disease is osteogenesis imperfecta type 3.