APOE 5’UTR region was divided into two smaller fractions, R1 (chr19:44,905,989-44,906,176, GRCh38/hg38) and R2 (chr19:44,906,058-44,906,285, GRCh38/hg38) for technical limitations, and their methylation pattern was analyzed in PBMCs of 40 subjects (AD n = 20; HC n = 20) and in HIC brain tissue of 9 subjects (AD n = 6; HC n = 3). Here, LGR5 is linked to Alzheimer disease.