While the low-glycemic/low-insulinogenic ancestral diet is associated with low OxS, high insulin sensitivity, no significant subclinical inflammation and impact on SNS activity [38, 47, 103, 104, 201], the high-glycemic/high-insulinogenic WD has a strong tendency to disrupt physiological balance and cause OxS, IR, hyperinsulinemia and dysregulation of the SNS, RAAS and immune system. The gene discussed is INS; the disease is Hyperinsulinemia.