However, although 1q42.2 is a region that has been linked with psychotic illness56,57 and although the TWIK-1/TREK-1 heterodimer has been proposed as a target for antidepressant drugs,58KCNK1 is explicitly not among the loci that have been associated with schizophrenia by GWAS59,60: Indeed, in a 2014 GWAS,56 rs701232 had a thoroughly nonsignificant P value of 0.2832. Here, KCNK1 is linked to schizophrenia.