BAG3 and myositis disease: Moreover, the circumstance, that specific molecules, which have a pathogenic counterpart in genetic myopathies (like hnRNP [27] and BAG3 [62]), interact with an antigen and operate in the pathogenesis of myositis has been seen in IMNM as well: Here, anti-HMGCR autoantibodies recognize the HMG-CoA-reductase protein.