Other data have shown that patients with IDH-mutant astrocytomas harboring mutations in genes known to be involved with maintenance of chromosomal stability in other cancer types (APC, BLM, BRCA1/2, the Fanconi anemia family genes, among numerous others) have higher overall CNA at the time of initial surgery and correspondingly poor clinical outcomes regardless of histologic grade [150, 174, 175, 177]. This evidence concerns the gene APC and cancer.