IDH2 and astrocytoma (excluding glioblastoma): There was also a small “epigenetically unstable” subgroup that converted rapidly from G-CIMP-high to G-CIMP-low status with recurrence that exhibited significantly worse clinical outcomes (with a predictive panel of 7 CpG sites) [55], similar to incongruously high CNA in low-grade IDH-mutant astrocytomas with rapid recurrence and patient death [10, 151, 172, 174, 176, 190].