Indeed, upon activation of ADRB2 receptors on an AD animal model, ameliorated mitochondrial dysfunction induced by Aβ and attenuated mitophagy deficits via the ADRB2/Akt/PINK1 pathway was reported [142]; findings indicate that ADRB2s may be a promising therapeutic target for AD. This evidence concerns the gene ADRB2 and Alzheimer disease.