Currently, we present the most comprehensive atlas for HER2-activating missense mutations in NSCLC (Fig. 4), encompassing molecular subtypes of various missense mutations across each exon of the HER2 receptor in NSCLC, documented or reported in datasets such as Cosmic, cBioPortal, and Foundation Medicine sequencing [9]. The gene discussed is ERBB2; the disease is non-small cell lung carcinoma.