Sugimoto et al. had reported plasma cell-free DNA (cfDNA) sequencing in patients with NSCLC showed relatively high sensitivity for detecting gene mutations but low sensitivity for gene fusions and MET exon 14 skipping, with a positive percent agreement of plasma cfDNA sequencing compared with tissue DNA and RNA assays were 77% (EGFR, 78%; KRAS, 75%; BRAF, 85%; HER2, 72%) and 47% (ALK, 46%; RET, 57%; ROS1, 18%; MET, 66%), respectively [40]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.