Pennisi et al. modified the Endothelial Activation and Stress Index (EASIX) score, used to predict outcomes in HSCT, by replacing creatinine with CRP to create the formula lactate dehydrogenase (LDH) x CRP/platelet count and found good association between development of severe CRS and ICANS and this modified score [47]. The gene discussed is CRP; the disease is congenital rubella syndrome.