Preclinical models of CAR-T-derived CRS have found that monocyte/macrophage-derived IL-1 and IL-6 are both important in the pathophysiology of CRS and ICANS and that blockade of IL-1 with anakinra alone is effective in mitigating CRS and ICANS [54, 77]. The gene discussed is IL6; the disease is congenital rubella syndrome.