In addition to the MAPK signaling pathway, the results of our enrichment analysis also suggest that there may be other pro-cancer mechanisms of ARPC1A in LGG, including the regulation of nucleic acid purine metabolism, the regulation of the mismatch repair process, and the impact of the cell cycle and other functions, and therefore, the regulatory mechanism of ARPC1A needs to be further explored in future studies. Here, ARPC1A is linked to cancer.