Mendelian randomization analysis demonstrated a causal association between genetically predicted FBN2 expression in the heart-left ventricle and hypertension (MR beta = −0.0139011, P value = 0.0001660731), as well as a causal link between JPH2 expression in the adrenal gland and hypertension (MR beta = 0.0141774, P value = 3.18939 × 10−6). This evidence concerns the gene FBN2 and hypertensive disorder.