INS and obesity due to melanocortin 4 receptor deficiency: Our findings are also directly relevant to the debate around the ‘carbohydrate‐insulin model’(CIM) of obesity, which proposes that high dietary carbohydrate increases post‐prandial insulin secretion, causing increased fat accumulation, increased hunger, excess energy intake and ultimately adiposity and metabolic dysfunction (Ludwig & Ebbeling, 2018).