Of note, downregulating this pathway through the use of siRNAs against Fyn or the p22phox subunit of NADPH oxidase reverts those PTMs on ERK1/2, p38, and JNK induced by prion infection, supporting the therapeutic potential of targeting Fyn or NADPH oxidase to protect neurons in prion diseases (Pradines et al., 2013). This evidence concerns the gene FYN and prion disease.