FMO5 and prion disease: Of note, downregulating this pathway through the use of siRNAs against Fyn or the p22phox subunit of NADPH oxidase reverts those PTMs on ERK1/2, p38, and JNK induced by prion infection, supporting the therapeutic potential of targeting Fyn or NADPH oxidase to protect neurons in prion diseases (Pradines et al., 2013).