Supporting the idea of an intricate link between PrPC PTM profiles, regionalized PTCC of PrPC into PrPSc, and prion strain-associated neuropathological lesions, post-mortem detection of spongiform degeneration in sporadic Creutzfeldt–Jakob disease (CJD) brain using diffusion MRI showed that the location of the epicenter and the propagation profile of lesions depend on the prion strain (Pascuzzo et al., 2020). The gene discussed is PRNP; the disease is Creutzfeldt Jacob disease.