Pharmacological inhibition of CaN with the immunosuppressive drug FK506 limits neurodegeneration, reduces motor deficits, and increases the survival of mice infected with RML or Fukuoka-1 strains (Mukherjee et al., 2010; Nakagaki et al., 2013), introducing an additional way of therapeutic intervention for prion diseases. The gene discussed is NUP214; the disease is prion disease.