In addition, daphnetin is believed to possess antitumor potential (Kumar et al., 2018; Deng et al., 2020), and exhibit potent antitumor effects in ovarian cancer by inducing ROS-dependent apoptosis, which relies on the Akt/mTOR pathway (Fan et al., 2021b). The gene discussed is AKT1; the disease is ovarian carcinoma.