In an SLE NZB/WF 1 mouse model, administration of daphnetin (at 5 mg/kg) once a day for 12 weeks reduced the organ damage caused by SLE, lowered the serum autoantibody production, and increased the survival rate of mice with SLE via suppressing RELA and NF-κB signaling pathways (Gatto et al., 2013). Here, RELA is linked to systemic lupus erythematosus.