Pretreatment of daphnetin at 4 mg/kg significantly blocks the TLR4/NF-κB signaling pathway by inhibiting the phosphorylation of IκBα and the expression of TLR4, thereby attenuating pancreatic injury in rat severe acute pancreatitis (SAP) model compared to the control group (Liu et al., 2016). Here, TLR4 is linked to acute pancreatitis.