These pathways exhibit notable enrichment in processes associated with anti-PC effects, encompassing Interleukin-4 and Interleukin-13 signaling, Signaling by Interleukins, Diseases of signal transduction by growth factor receptors and second messengers, Cytokine Signaling in Immune system, and Extra-nuclear estrogen signaling. This evidence concerns the gene IL13 and pachyonychia congenita.