Previous study (Gong et al., 2020) has demonstrated that after treatment with CHF, serum levels of oxidation-antioxidant related biomarkers malondialdehyde (MDA), superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) in A on C patients showed significant changes compared with those before treatment, which showed levels of HO-1 and SOD in patients with A on C were higher than those before treatment, and MDA levels were lower. The gene discussed is SOD1; the disease is congestive heart failure.