We hypothesize that selected patients at high risk for the development of invasive cancers may require intensified, tailored, and targeted treatment, possibly including immunotherapy (e.g., anti-PD-1/PD-L1 (5, 6)) and anti-human epidermal growth factor receptor 2 (HER2) therapy, as offered to patients diagnosed with IBC (7–10). The gene discussed is ERBB2; the disease is inflammatory breast carcinoma.