Among the 31 patients, 137 lymph node metastases were examined in 23 patients, and all 137 lymph nodes were accurately identified for lymph node involvement using 68Ga-FAP-2286 PET/CT, whereas only 108 of the 137 lymph node metastases were correctly diagnosed employing 18F-FDG PET/CT. Here, FAP is linked to metastatic malignant neoplasm in the lymph nodes.