Among the listed ECM genes (Figure 4B), two types were noted, those that were low in mono-cultures and high in co-cultures (e.g. COL1A, FN, LAMA1, primarily fibroblast-derived) and those that were high in both mono- and co-cultures (e.g. LAMA5 and LAMB1, primarily cancer cell-derived). Here, FN1 is linked to cancer.