TNFRSF1A and type 2 diabetes mellitus: Tumor necrosis factor 1 receptor (TNFR1) and Tumor necrosis factor 2 receptor (TNFR2): Elevated serum TNFR1 and TNFR2 concentrations are strong independent predictors of renal function decline leading to ESRD in patients with T2D. Elevated serum concentrations of TNFR1 or TNFR2 in T2D are associated with early glomerular structural lesions.