In addition, interferon-inducible protein 16 (IFI16) (an innate immune sensor of intracellular DNA) and cytosolic dsDNA puncta of mitochondrial origin accumulate in the brains of patients with PD.229 Notably, IFI16 has the ability to the recruitment of STING and the production of IFN-I, or else forms the inflammasome with apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) to induce the production of IL-1β and IL-18. This evidence concerns the gene IFI16 and Parkinson disease.