Succinic semialdehyde dehydrogenase deficiency (SSADHD, OMIM #271980) due to biallelic variants in ALDH5A1, is one such rare neurometabolic disorder (Jakobs et al., 1981; Gibson et al., 1983). Here, ALDH5A1 is linked to succinic semialdehyde dehydrogenase deficiency.