This gene belongs to the CXC-type chemokine family and plays a crucial role as a key mediator in the inflammatory response. It can be secreted by various cell types, including leukocytes, fibroblasts, endothelial cells, and malignant tumor cells. Its biological effects are mediated through the binding of two GPCRs, namely, CXCR1 and CXCR2. Here, CXCR2 is linked to cancer.