To exclude possible genetic overlap with other nervous system diseases such as SCAs and amyotrophic lateral sclerosis (9, 18) and to further exclude dynamic mutations, large fragment deletions or duplication mutations, a panel of SCA-related gene (ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, ATXN8, ATXN10, PPP2R2B, TBP, and ATN1) testing was also conducted, using gene microarray analysis. This evidence concerns the gene PPP2R2B and nervous system disorder.