Although the underlying mechanisms of COVID-19 and subsequent acute kidney disorder remain unclear, it could be speculated that COVID-19 might be a direct (such as a change in renal blood flow, toxicity, ischemic injury, or cytokine storm) [43] or indirect (such as binding with angiotensin-converting enzyme-2 highly expressed in the proximal tubule of the kidney) cause of kidney function change, and some debates still exist about the its causal relationship [44]. Here, ACE2 is linked to COVID-19.