Differentials comprise prolonged aPTT attributable to vitamin K deficiency, anticoagulants, antiphospholipid syndrome, disseminated intravascular coagulation, acquired vWF deficiency, etc. Due to the possible uncontrolled bleeding in individuals without a previous history of bleeding disorder, delayed diagnosis and management are common, which can lead to serious morbidity and mortality in these patients. The gene discussed is VWF; the disease is antiphospholipid syndrome.