Differentials comprise prolonged aPTT attributable to vitamin K deficiency, anticoagulants, antiphospholipid syndrome, disseminated intravascular coagulation, acquired vWF deficiency, etc. Due to the possible uncontrolled bleeding in individuals without a previous history of bleeding disorder, delayed diagnosis and management are common, which can lead to serious morbidity and mortality in these patients. This evidence concerns the gene VWF and Disseminated intravascular coagulation.