At pFDR<0.05, eight CSF proteins (APOE, PILRA-M14, PILRA-deltaTM, FcRIIIa, BGAT, PLA2R, TIMD3 and TPSNR) and four plasma proteins (EphB4, HTRA1, PILRA-M14, PILRA-deltaTM) were significantly associated with AD, while one CSF protein (BGAT, measuring histo-blood group ABO system glycosyltransferase activity) and one plasma protein (FBLN3) were associated with any stroke and ischemic stroke (Supplementary Tables 20–21). Here, HTRA1 is linked to Alzheimer disease.