At pFDR<0.05, eight CSF proteins (APOE, PILRA-M14, PILRA-deltaTM, FcRIIIa, BGAT, PLA2R, TIMD3 and TPSNR) and four plasma proteins (EphB4, HTRA1, PILRA-M14, PILRA-deltaTM) were significantly associated with AD, while one CSF protein (BGAT, measuring histo-blood group ABO system glycosyltransferase activity) and one plasma protein (FBLN3) were associated with any stroke and ischemic stroke (Supplementary Tables 20–21). This evidence concerns the gene HTRA1 and ischemic stroke.