Interestingly, previous experimental work has supported PILRA as the likely causal gene at the chr7q21 AD risk locus,42 suggesting that a common missense variant in this gene (rs1859788, r2 = 0.3 with PILRA pQTL) may protect against AD via reduced inhibitory signaling in microglia and reduced microglial infection during HSV-1 recurrence. Here, PILRA is linked to Alzheimer disease.