We identified such drugs for EPO, LTF, TFPI, and EPHB4 for WMH; COL6A1, GPNMB, PCSK9 for PVS, most of which were associated with MRI-cSVD in the CSF only, except EPHB4 (plasma), EPO and TFPI (CSF and plasma, Fig. 5, Supplementary Table 28). Here, EPHB4 is linked to perivascular space measurement.