Nine of these (24%) were associated with the same MRI-cSVD phenotype in plasma at pFDR<0.05 (APOE, ARSB, EPO, AMD, CTSS, PSMP with WMH, PILRA-M14, PILRA-deltaTM, KTEL1 with WM-PVS, Methods, Fig. 3A and 6, Supplementary Table 10). This evidence concerns the gene APOE and age-related macular degeneration.