To examine interactions between EHMT2 and the maternal and paternal alleles of the PWS-IC, we performed ChIP analysis in human fibroblasts derived from a patient with PWS (a 6Mb paternal deletion of 15q11.2-q13) and a patient with AS (a 6 Mb maternal deletion of 15q11.2-q13) (Fig. 2a, 2b). Here, EHMT2 is linked to Prader-Willi syndrome.