In our large-scale small molecule screen in Snrpn-EGFP mouse embryonic fibroblasts, we discovered that inhibitors of the nuclear histone lysine methyltransferase EHMT2, also known as G9a, were capable of unsilencing the imprinted SNRPN and SNHG14 genes from the maternal chromosome, both in human fibroblasts derived from patients with PWS and in a PWS mouse model21. Here, EHMT2 is linked to Prader-Willi syndrome.