SERPINE1 and congenital dyserythropoietic anemia: However, according to the multivariate logistic regression analysis, only low serpin E1/PAI-1 [OR (95%CI) 0.026(0.002–0.437); P = 0.011] and highROBO4 [OR (95%CI) 7.624(1.548–37.558); P = 0.013] were independent risk factors for severe CDA in patients with FCCM (Table 2).