However, low E1/PAI-1 [OR (95%CI) 0.012 (0.000–0.491)] and high ROBO4 levels [OR (95%CI) 11.797 (1.483–93.844)] were still associated with severe CDA in patients with FCCM when analyzed using the GLMM. This evidence concerns the gene ROBO4 and congenital dyserythropoietic anemia.