PIK3R1 and type 2 diabetes mellitus: Previously, 31 variants across 28 T2D risk loci were reported to have sex-specific effects on T2D in a trans-ancestry GWAS, including one variant near the same TM6SF2 locus.36 We also found differentially accessible regions to overlap with classical T2D variants in male but not female δ cells (GCK, KCNQ1 and PIK3R1), endothelial cells (HNF1A and NEUROG3), and acinar cells (SLC30A8).