Previously, 31 variants across 28 T2D risk loci were reported to have sex-specific effects on T2D in a trans-ancestry GWAS, including one variant near TM6SF2 (rs8107974), two variants at GLI2 (rs11688931, rs11688682), and one variant at KCNQ1 (rs2237895).36 Inclusion of two additional T2D meta-analyses which included the X-chromosome found no additional overlap in T2D risk loci with differentially accessible chromatin regions on the X-chromosome.37,38. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.