In our experimental findings, we demonstrated that CX3CL1 was only detected in the supernatants of MTX-treated immunogenic apoptotic fibrosarcoma MCA205 and melanoma B16-F10 cells, and to a significantly lesser extent in the supernatants of viable cancer cells, RSL3-treated non-immunogenic late ferroptotic (6) cancer cells and non-immunogenic F/T accidentally necrotic cancer cells (Figures 1C, F). Here, CX3CL1 is linked to cancer.