Neuroinflammation causes hippocampal atrophy (116), which may play an important role in the development of AD (109, 114). A study showed that injecting plasma from aging mice or CCL11 into young mice impaired learning and memory and decreased adult neurogenesis, suggesting that CCL11 is involved in the decline of hippocampal function during aging (116). Here, CCL11 is linked to hippocampal atrophy.